# why muscles get tired
**URL:** https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801
**Category:** RPGC Main Forum
**Created:** [February 11, 2008, 4:10pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801 "2008-02-11T16:10:40Z")
**Posts on this page:** 20
**Page:** 1
### Author:  [@Sinistral](https://discourse.rpgclassics.com/u/Sinistral)
#### Post date: [February 11, 2008, 4:10pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/1 "2008-02-11T16:10:40Z")
This article is COOL.
> **[Finding May Solve Riddle of Fatigue in Muscles](https://www.nytimes.com/2008/02/12/health/research/12musc.html?ref=health)**
>
> Scientists are reporting that they have determined why muscles get tired and devised, for mice, an experimental drug that can eliminate fatigue.
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### Author:  [@Lex](https://discourse.rpgclassics.com/u/Lex)
#### Post date: [February 11, 2008, 4:54pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/2 "2008-02-11T16:54:04Z")
The article seems to suggest that repairing the calcium channels would negate or even prevent the damage done by the enzymes. But what would happen if the channels were repaired shortly after they began leaking when there would be some active enzymes in the muscles?
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### Author:  [@Sinistral](https://discourse.rpgclassics.com/u/Sinistral)
#### Post date: [February 11, 2008, 5:33pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/3 "2008-02-11T17:33:33Z")
The channels take time to be replaced. You don’t magically bake up new proteins, that’s why the article says it takes days.
Enzymes would keep doing their thing as long as calcium is present, as enzymes are catalysts. The calcium doesn’t get used up as they do their actions. Odds are, what you’re saying , there would simply be less damage done but there would still be damage until the enzymes pooped out.
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### Author:  [@Xwing1056](https://discourse.rpgclassics.com/u/Xwing1056)
#### Post date: [February 11, 2008, 5:51pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/4 "2008-02-11T17:51:25Z")
My understanding is that most unpleasant “symptoms” are actually defense mechanisms against more serious problems. Otherwise, there’s no reason they would have evolved. E.g. A fever kills or slows the reproduction of bacteria. Excess mucus catches germs that would be inhaled. Sleepiness prevents death due to lack of sleep (a phenomenon that is not very well understood). The article alludes to a concern, which I instinctively share, that preventing muscles from growing tired and continuing to strain them may lead to something worse than muscle fatigue.
Nonetheless, I imagine that soon every energy drink will claim to eliminate muscle fatigue, beyond the brain fatigue that caffeine already eliminates.
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### Author:  [@Sinistral](https://discourse.rpgclassics.com/u/Sinistral)
#### Post date: [February 11, 2008, 5:56pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/5 "2008-02-11T17:56:46Z")
I agree, we have to wonder if the pain and soreness is a byproduct of another pathway. In general, my guess is that the muscle cells should die from excess calcium intake because calcium makes cells go spastic, to use lay men’s terms. I’m a bit surprised they haven’t seen any side effects to their drugs. I’m going to look for the actual research paper on the subject tomorrow at my lab when I get a minute to see what they specifically did. It is still a possibility that its just a product of biological imperfection, although I really would be surprised there is NO side effects.
In regards to sleep, sleep isn’t made to prevent death, though it is a bad side effect of not sleeping. Sleep has been found to be essential in the process of synaptic pruning and rewiring your brain after a given set of experiences. You need sleep to function and process information over time.
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### Author:  [@Cless\_Alvein](https://discourse.rpgclassics.com/u/Cless_Alvein)
#### Post date: [February 11, 2008, 8:08pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/6 "2008-02-11T20:08:55Z")
Well, we’ll have to wait for stage 2 trial results if they manage to synthesize a drug successfully
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### Author:  [@Sinistral](https://discourse.rpgclassics.com/u/Sinistral)
#### Post date: [February 11, 2008, 8:18pm UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/7 "2008-02-11T20:18:12Z")
my guess is that making the drug probably isn’t that hard from the sound of it. But you’re right. For now, the world is a safer place for mice.
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### Author:  [@Rigmarole](https://discourse.rpgclassics.com/u/Rigmarole)
#### Post date: [February 12, 2008, 4:47am UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/8 "2008-02-12T04:47:20Z")
That’s interesting. I wouldn’t bet on seeing a more permanent anti-fatigue drug soon (or ever), but understanding how the tiring mechanism works is good. I suppose understanding the biological use of tiring is the next step or do we already have this?
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### Author:  [@Wilfredo\_Martinez](https://discourse.rpgclassics.com/u/Wilfredo_Martinez)
#### Post date: [February 12, 2008, 7:31am UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/9 "2008-02-12T07:31:30Z")
If they do produce an antifatigue drug for humans -even if only an unsafe one- you can bet that, sadly, it will get used in sport competitions. Just look at all the doping scandals last year, in Major League baseball and even the Tour de France. ☹
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### Author:  [@Rhaka](https://discourse.rpgclassics.com/u/Rhaka)
#### Post date: [February 12, 2008, 9:40am UTC](https://discourse.rpgclassics.com/t/why-muscles-get-tired/19801/10 "2008-02-12T09:40:38Z")
> [@Wilfredo\_Martinez](#):
>
> If they do produce an antifatigue drug for humans -even if only an unsafe one- you can bet that, sadly, it will get used in sport competitions. Just look at all the doping scandals last year, in Major League baseball and especially the Tour de France. ☹
\